EventsAssist. Prof. Sündüs Erbaş Çakmak
Artificial molecular machines and devices made up of mechanically interlocked molecules
Random thermal motion (Brownian motion) of a tiny particle can be biased with the addition of extra energy to make artificial molecular machines capable of directional rotary or translational motion. Mechanically interlocked molecules can display unique chemical and mechanical properties where the independent components cannot, and relative motion of the components can be utilised to ratchet particle’s motion, drive systems out-of-equilibrium or to regulate reaction rate, type and selectivity. First part of the presentation will cover our novel approaches to get directional rotary and translational motion using mechanically interlocked molecules. In these motor molecules, dynamic covalent chemistry and orthogonal supramolecular interactions (chemical energy) are used to ratchet molecule’s motion in a 1D track. In the second part of the presentation, unique structural properties of interlocked molecules and their potential applications will be explored. Progress in processive, encodable, sequence specific peptide synthesis with artificial small-molecule ribosome mimic will be presented. Very first switchable asymmetric catalysis with mechanically point-chiral rotaxane catalysts will be highlighted and the future directions to develop functional materials by utilising supramolecular architectures will be discussed.
About The Speaker
Sündüs Erbaş Çakmak obtained her B.Sc. degree in Molecular Biology and Genetics Department in 2007 from Boğaziçi University. She got her M.Sc. (2009) and Ph.D. degrees (2013) from Materials Science and Nanotechnology Program of Bilkent University, investigating integration and the use of molecular logic gates for the activity modulation of photodynamic therapy agents. She worked at Indiana University in the United States of America, as a TÜBİTAK PhD-abroad scholar for 6 months during her Ph.D., with a research focus on the development of fluorescent anion sensors. In 2013 she started to work at University of Manchester in United Kingdom, as a Marie-Curie Intra-European Post-Doctoral Fellow. Since April 2016, she is working as an Assistant Professor at the Molecular Biology and Genetics Department of Konya Food and Agriculture University. Her research interests include artificial molecular machines, supramolecular catalysis, artificial enzymes and chemical biology.