EventDr. Yannick Rondelez

DNA-based Networking

Complex behaviors can be produced -or controlled- by networks of simple elements connected in larger systems and submitted to an energy flow. At the molecular level, this is exemplified by impressive biological phenomena such as genetic regulation, morphogenesis, or the immune system, all implemented by dedicated chemical reaction networks.

In contrast to physics or engineering, where the concept of networks is important and fertile, chemistry has little explored this direction. One of the reason is synthesizing out-of-equilibrium chemical reaction networks with precisely designed structures, and hence behaviors, is very difficult.

We are developing “universal” in vitro chemistries leveraging the availability and programmability of synthetic DNA oligonucleotides. These approaches can be used to create dissipative, non-linear reaction network of any topology. This is because the necessary nodes (the molecular compounds) can always be found as short DNA strands.

I will present some proof-of-concept example and discuss possible applications of DNA-based molecular programming, in combination with microfluidic approaches.

DNA-based networking

About The Speaker

Yannick Rondelez

Yannick Rondelez is a CNRS scientist working at ESPCI in Paris. His research interests focus on the relation between molecular sciences and information processing. He has a physical-chemistry background, with a strong biological focus. After a Ph.D. spent on synthesizing bioionorganic models of enzymes, he went on with a postdoc on the biophysics of molecular motors (the rotary F1-ATPase). His current goal is to apply the principles of biological information processing to the design of artificial molecular assemblies with complex dynamic behaviors and responses. He is also exploring the concept of developing tailored molecular algorithms to address practical (bio)-chemical challenges.