Epigenetic scars of infectious diseases: Trained immunity
Immunological memory has traditionally been attributed to be a function of adaptive immune system, which is present in higher organisms. T cell activation play a central role in mounting a highly specific response to the invading organisms / non-self structures. Yet, the activation process also yields an immunological memory, in order to provide protection against the future encounters of the same pathogen. Specific metabolic signature profiles exist for naive, activated and memory states of these T cells. Recently, it has been discovered that, upon activation, cellular components of innate immunity also proceed through similar metabolic changes. The irreversible nature of polarization process of macrophages vastly depend on epigenetic mechanisms, thus considered to induce a change in entropy of cellular data content. Once set in, this form of macrophage activation provides sustained memory for cross protection against various pathogens.
About The Speaker
After graduating from Hacettepe University Faculty of Medicine in 1997, I earned clinical microbiolgy specialist degree in 2003 at the same university, where I mainly focused on pathophysiology and diagnosis of Helicobacter pylori infections. Between 2003 and 2008 I continued microbiology PhD program and quorum sensing research in Gazi University. Since 2009, I have been carrying on my research in Ankara University Biotechnology Institute with two MSc students. The stress imposed on microbial cell factories in heterologous recombinant protein, synthetic antibody and metabolite production, as well as the effect of small signal molecules that control the cell behaviour is in my primary research area. Currently, me and my study group is involved in the development of cheap and efficient designs in sensors, control electronics, mechanics and software for process control in fermenter systems.