EventsProf. Guido H. Clever
Guest-binding and Structural Reorganization in Stimuli-responsive Coordination Cages and DNA G-Quadruplexes
The square-planar metal(pyridine)4-motif has proven its value in many self-assembled structures such as helicates, spherical cages and coordination networks. We have prepared a number of discrete mono- and oligonuclear (n = 2 – 6) architectures based on various organic and DNA-derived ligands containing this motif with PdII, PtII, CuII or NiII as the metal center. The talk will highlight functional assemblies including reversibly stabilized DNA-quadruplexes1 and guest-binding coordination cages.2
A focus will be laid on stimuli-responsive systems. In a series of interpenetrated double-cages [Pd4Ligand8], comprising a variety of organic ligands, phenomena such as allosteric and triggered guest binding were observed. We further examine photochromic coordination cages based on dithienylethene (DTE) ligands that allow for reversible control over uptake and release of spherical guests and light-triggered structural reorganization processes.3 Currently, we work on strategies enabling a rational multifunctionalization of self-assembled nanoarchitectures.4
(1) a) D. M. Engelhard, R. Pievo, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 12843;
b) D. M. Engelhard, J. Nowack, G. H. Clever, Angew. Chem. Int. Ed. 2017, 56, 11640.
(2) Reviews: a) M. Han, D. M. Engelhard, G. H. Clever, Chem. Soc. Rev. 2014, 43, 1848; b) M. Frank, M. D. Johnstone, G. H. Clever, Chem. Eur. J. 2016, 22, 14104; c) G. H. Clever, P. Punt, Acc. Chem. Res. 2017, 50, 2233.
(3) a) M. Han, R. Michel, B. He, Y.-S. Chen, D. Stalke, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 1319; b) M. Han, Y. Luo, B. Damaschke, L. Gómez, X. Ribas, A. Jose, P. Peretzki, M. Seibt, G. H. Clever, Angew. Chem. Int. Ed. 2016, 55, 445.
(4) a) W. M. Bloch, Y. Abe, J. J. Holstein, C. M. Wandtke, B. Dittrich, G. H. Clever, J. Am. Chem. Soc. 2016, 138, 13750; b) W. M. Bloch, J. J. Holstein, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed. 2017, 56, 8285.
About The Speaker
Prof. Clever is graduated from Ruprecht-Karls University, Chemistry Department in Heidelberg. He earned his PhD degree from Munich Ludwig Maximilian University in 2006. Later he moved to Tokyo University and carried out his postdoctoral studies in supramolecular and bioinorganic chemistry supported by Japan Society for the Promotion of Science and the Alexander von Humboldt Foundation (2007 to 2009). After his postdoctoral work, he became a junior Professor in Inorganic Chemistry at Göttingen University in 2010. He was promoted to full Professorship in 2013 in the same University. Currently, Prof. Clever is the chair of Bioinorganic Chemistry Department at Technical University of Dortmund.
Prof. Clever earned many awards including Kekulé Fellowship, and a recent ERC Consolidator award. Prof. Clever’s research interest includes supramolecular chemistry, chemistry inside molecular cages, dna-metal-interactions, redox materials.