EventAsst. Prof. Selim Hanay

Multimode Resonant Sensing:
From Inertial Imaging with NEMS to Microdroplet and Cell Characterization with Microwave Sensors

Selim-Hanay-Abstract-figure

Nanomechanical resonant devices can be used as exquisite sensors for mass, force and charge detection. A popular trend in recent years has been the use of multiple modes of nanomechanical sensors. When multiple modes of a resonant sensor are tracked, shape information about analytes can be obtained. In the context of micro and nano-mechanical sensors, multimode measurements provide the size and shape information —as well as the mass— of an analyte. By processing the spatial information, an image can be reconstructed [1]. This technique, Inertial Imaging, transforms the capabilities of nanomechanical sensors to a new level: the combined knowledge of molecular mass, size and shape of the analyte can enable previously unattainable information for biomolecular analytics. The technique can be extended to two-dimensional resonators: for instance, the first six modes of a mechanical membrane enables for the determination of the location, size and orientation of an analyte. These principles, originally developed for nanomechanical sensors, can be extended to electromagnetic resonant sensing as well. By embedding microfluidic channels between the signal line and ground plane of a microstripline resonator, the excess electrical volume and position of microdoplets have been measured [2]. The same sensors can also be used to obtain electrical and size characteristics cells such as HeLa and MDA-MB-157 cell lines. Sensing with higher order modes in this platform can yield further spatial properties of analytes, eventually enabling a construction of an image for cells at the microwave band.

[1] Hanay, M. S., Kelber, S. I., O’Connell, C. D., Mulvaney, P., Sader, J. E. & Roukes, M. L., Inertial Imaging with Nanomechanical Systems. Nature Nanotechnology 10, 339-344 (2015).

[2] Kelleci, M., Aydogmus, H., Aslanbas, L., Erbil, S. O., & Hanay, M. S. (2017). Spatially Resolved Sensing in Microfluidics with Multimode Microwave Resonators. arXiv preprint arXiv:1702.06056.

About The Speaker

Selim-Hanay-Bio

Asst. Prof. Selim Hanay received his Ph.D. degree in Physics from Caltech in 2011 where he has developed nanomechanical sensors capable of detecting and weighing single protein molecules in real time. He continued his research at Caltech first as a post-doctoral research fellow and then as a research engineer. In 2013, he joined Bilkent University as an Assistant Professor. His current research focuses on multimode sensing with nanomechanical and microwave sensors. He is the recipient of a gold medal in the 31st International Chemistry Olympiads, and Young Scientist awards by Science Academy (Bilim Akademisi) and Turkish Academy of Sciences (TÜBA). He has been awarded with an FP7 Marie-Curie Career Integration Grant and an ERC Starting Grant.