EventsDr. Aykut Erbaş

Stimuli-Response in Polymeric systems; from Energy Applications to Biological
Phenomena

Polymers are one of the most versatile building blocks to construct stimuli-­‐responsive soft matter for scientists and nature, thanks to their structural and chemical diversity. While scientists use their tailorable properties to design functional and hybrid materials, nature facilitates them for organization and adaptability. However, everything comes at a cost. The heterogeneities in the zoo of polymers bring complexity, particularly when we need to know their physiochemical responses to distortions, which are essential to design robust materials and resolve certain biological questions quantitatively. Yet, to make life even harder, most synthetic and biological polymeric systems of interest carry ionic groups that can interact beyond inter-­‐atomic distances. These long-­‐ range interactions are cumbersome to treat analytically alone and necessitate computational solutions. Along with these lines, in the first part of my talk, I will discuss the electro-­‐mechanical responses of polyelectrolyte networks (i.e., hydrogels), which are not only excellent materials for filtration and electrolyte applications but also quite abundant in living organisms. The extensive computational simulations demonstrate that mechanical deformation of chains constituting the hydrogel leads to enhanced ionic correlations and allow an “energy conversion” process. Ionic conductivity  in  these  networks  exhibits  strong  non-­‐linearity  regardless  of  solvent  properties, similar to ionic diodes. In the second part, I will change gear and discuss the role of ionic interactions in ligand dissociation kinetics by specifically focusing on the experiments and simulations  of  facilitated  disassociation  of  transcription  factors  from  single-­‐DNA-­‐binding  sites. The  research  shows  that  weak  inter-­‐molecular  interactions  can  be  a  key  factor  in  regulatory networks and thus for some biotechnological applications. I will conclude my talk with future prospects to improve and control ionic motion in polymer matrices, and with some preliminary computational results on chromatin segregation in eukaryotic cell nuclei.

aykut_erbas_abs

About The Speaker

Aykut_Erbas

Dr. Aykut Erbas received his Ph.D. in Physics from Technical University Munich (TUM) -­‐ Germany in 2011 under the advisory of Roland R. Netz. During his graduate studies, he worked on peptide-­‐ surface  interactions  and  single-­‐molecule  friction.  His  thesis  work  revealed  the  contributions  of cooperative rupture of hydrogen bonds on molecular mobility. Later he moved to the University of North Carolina -­‐ Chapel Hill, Chemistry Department, to research polymer dynamics with Michael Rubinstein. Since 2014, Dr. Erbas has been a research fellow at Northwestern University’s Material Science & Engineering Department in various centers dedicated to designing bio-­‐inspired energy systems with Monica Olvera de la Cruz. In his research, Dr. Erbas utilizes computational simulations and theoretical models, and collaborates with various experimental groups to explore phenomena in charged polymeric systems, including hydrogels, ionic liquids, amphiphilic peptides.   In   addition   to   his   materials-­‐oriented   studies,   he   also   researches   DNA-­‐protein interactions and in vivo chromatin conformations with John F. Marko, a pioneering biophysicist on DNA mechanics.