A Therabostic Bio-Device for Biomedical Applications
Living therapeutics is an emerging concept that refers repurposing microorganisms to perform complex theranostic tasks inside the human body. These autonomous bio-machines promising a revolution on the treatment strategies of many diseases. Besides, they are providing a cheaper yet specialized way of medication for the different health conditions that are highly debated in terms of cost and the efficiency of the treatment. In this thesis, we are proposing a smart biological design that operates complete stages of the treatment of type II diabetes in a single bacterial cell. By using a natural resident of our body, a probiotic strain known as E. coli Nissle 1917, we are proposing engineering strategies to detect glucose levels in human body and respond by releasing therapeutic molecules from the cell surface.