EventsProf. Kenneth Dawson

Using Interactions between Nanoparticles and Receptors to Target Delivery

We argue that the path to discovery in nanotherapeutics, and to assuring safety,  is increasingly converging towards a more reductionist and microscopic understanding of the interactions between nanoparticles and receptor targets. This is a natural progression from the early phenomenological approaches.

It involves understanding the molecular detail at the particle surface, and then how that evolves in situ in more realistic in vivo scenarios. These ideas can all be validated by explicit receptor studies. We show for example how the likely liver-particle interactions can be understood by such methods.

 

  1. Nature Communications 7, 13475 (2016)
  2. J. Am. Chem. Soc. 139, 111 (2017)
  3. 3.ACS Nano, Article ASAP, DOI: 10.1021/acsnano.6b07933

About The Speaker

Professor Kenneth A. Dawson is Director of the Centre for BioNano Interactions (CBNI). The scientific focus of this Centre is to understand the interaction of nanoparticles with living systems (www.ucd.ie/cbni). The Centre seeks to clarify the controlling factors for these interactions, and to support applications in nanotherapeutics and nanosafety.

Prof. Dawson is Chair of Physical Chemistry, Chairman of the National BioNanoscience Action, and co-ordinator of the European Infrastructure in the area. He has experience in the management of large scale EU projects, including multi-sectoral cross-disciplinary research projects and other international programs. He has received several international prizes, including the 2007 Cozzarelli prize from the National Academy of Sciences USA, as well as IBM, Packard, Canon, Sloan and Dreyfus prizes.

Prof. Dawson’s professional roles include representing Ireland on various international bodies, including the OECD and ISO working groups on standards for Nanotechnology. He has been an advisor on nanoscience matters in the EU New Risk Committee of the European Commission, as well as the Advisory group of the European Medicines Agency.