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X-WR-CALNAME:UNAM Nanoteknoloji Araştırma Merkezi
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TZID:Europe/Moscow
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DTSTART:20260101T000000
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DTSTART;TZID=Europe/Moscow:20260415T110000
DTEND;TZID=Europe/Moscow:20260415T123000
DTSTAMP:20260905T164922
CREATED:20260406T124116Z
LAST-MODIFIED:20260407T051250Z
UID:10597-1776250800-1776256200@unam.bilkent.edu.tr
SUMMARY:Building a minimal nucleus to understand structure and  mechanics of assembly
DESCRIPTION:Alexander Von Appen\nMPI of Molecular Cell Biology and Genetics \n\nThe nucleus\, the largest organelle in human cells\, plays a crucial role in protecting\, organizing\, and regulating our genome. Despite its complexity\, it undergoes remarkable dynamics during cell division: as the cell enters mitosis\, nuclear organization dissolves\, leading to the detachment of the nuclear membrane from chromatin. The nucleoplasm and cytoplasm merge into a single entity\, while the spindle distributes chromosomes to form daughter cells. Following this “open” mitosis\, the entire organelle reassembles within minutes\, prompting the central question: what molecular mechanisms drive nuclear self-assembly? \nI will present our latest efforts to reconstitute nuclear self-assembly processes\, which we study structurally using cryo-electron tomography and mechanically using optical tweezers. Specifically\, I will show how ESCRT proteins assemble to close the nuclear membrane and how DNA is organized at the chromatin–nuclear membrane interface. \n \n  \n  \nAbout speaker\nPhD\, EMBL Heidelberg\, with Martin Beck\, studying the structure of the human nuclear pore complex PostDoc\, UCSF San Francisco\, with Adam Frost\, studying the role of phase separation in ESCRT-mediated nuclear membrane assembly Since 2021\, Research Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics\, Dresden\, Germany \n \n 
URL:https://unam.bilkent.edu.tr/en/event/building-a-minimal-nucleus-to-understand-structure-and-mechanics-of-assembly/
CATEGORIES:Nanocolloquium Series
ATTACH;FMTTYPE=image/jpeg:https://unam.bilkent.edu.tr/en/wp-content/uploads/2026/04/Von-Appen.jpg
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