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X-WR-CALDESC:Events for UNAM Nanoteknoloji Araştırma Merkezi
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DTSTART:20250101T000000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Moscow:20250703T154000
DTEND;TZID=Europe/Moscow:20250703T170000
DTSTAMP:20260906T010718
CREATED:20250627T055641Z
LAST-MODIFIED:20250627T055723Z
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SUMMARY:Smart Biomaterials and Biopreservation to Improve Human Health
DESCRIPTION: Ayşe Aslıhan Gökaltun\nMassachusetts General Hospital\, Harvard Medical School \n\nAdvancements in biomaterials and biopreservation technologies are critical to overcoming key bottlenecks in clinical care\, from wound management to organ transplantation. To highlight the state-of-the-art in these fields and reflect on current challenges and opportunities\, this talk will first present our development of stimuli-responsive supramolecular hydrogels to enhance wound healing\, deter infection and provide pain-free burn care for patients. These hydrogels are engineered to be tunable\, biocompatible\, and scalable for translational deployment. \nIn parallel\, I will share our progress in supercooled biopreservation\, where we extended the functional viability of primary hepatocyte monolayers up to three days\, preserving both morphology and metabolic function. This work opens avenues for long-range transport and banking of engineered tissues\, with implications for cell-based therapies and donor organ preservation. Together\, these technologies highlight the potential of smart biomaterials and biopreservation strategies to improve clinical applications and expand the reach of next-generation therapies. \n  \nAbout speaker\nDr. Aslihan Gokaltun is a faculty member at the Center for Engineering in Medicine and Surgery at Harvard Medical School and Massachusetts General Hospital. She joined the faculty in 2021 after completing her postdoctoral training in the laboratories of Drs. Martin Yarmush and Berk Usta where she co-led several federally funded initiatives. Dr. Gokaltun received her BSc\, MSc\, and PhD in Chemical Engineering from Hacettepe University in Türkiye. Her research focuses on engineering next-generation biomaterials and preservation strategies to enhance wound care and therapeutic delivery\, bridge preclinical and clinical domains\, and address unmet medical needs across diverse patient populations. \n 
URL:https://unam.bilkent.edu.tr/en/event/smart-biomaterials-and-biopreservation-to-improve-human-health/
CATEGORIES:UNAM Seminars
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DTSTART;TZID=Europe/Moscow:20250710T154000
DTEND;TZID=Europe/Moscow:20250710T170000
DTSTAMP:20260906T010718
CREATED:20250707T110044Z
LAST-MODIFIED:20250707T110044Z
UID:9911-1752162000-1752166800@unam.bilkent.edu.tr
SUMMARY:Engineering Tissues Layer by Layer: 3D Bioprinting with Bioinspired Nanomaterials
DESCRIPTION:Ahmad Rashad Elsebahy\n1- Center of Translational Oral Research\, Department of Clinical Dentistry\,\nUniversity of Bergen\, Norway.\n2- Bioengineering Graduate Program\, University of Notre Dame\,\nNotre Dame\, Indiana\, United States.\n3- Terasaki Institute for Biomedical Innovation\, Los Angeles\,\nCalifornia\, United States. \n\nDespite significant advances in science and technology\, we are still unable to fully overcome simple medical conditions like tooth cavities and bone fractures\, not to mention more serious diseases. To achieve true healing\, there is a growing need to shift the current medical paradigm toward regenerative strategies that can restore both the structure and function of native tissues. However\, living tissues are inherently sophisticated structures\, composed of multiple cell types embedded within multiscale\, multi-material composites precisely organized in layers to perform specific biological and mechanical functions. These natural matrices range from the nanoscale\, where molecules self-assemble into functional architectures\, all the way to centimeter-scale tissues\, as seen in human bones or plant structures like trees. Bones and trees have remarkable structural and molecular similarities. At the nanoscale\, the helical arrangement of collagen fibrils in bone closely resembles the arrangement of cellulose fibers in wood. Both structures are optimized to withstand mechanical stress. This structural-functional complexity presents both a challenge and blueprint for developing advanced tissue engineering strategies. Achieving such structural and functional fidelity requires advanced fabrication technologies\, such as 3D bioprinting\, which enables the accurate positioning of bioinks composed of diverse cells\, biomaterials\, and biologics in layer-by-layer architectures that closely recapitulate the native tissue environment. \nThis lecture will highlight some of my previous work on the integration of extrusion-based bioprinting with bioinspired nanomaterials\, specifically cellulose nanofibers and nanohydroxyapatite\, to fabricate scaffolds that replicate the architecture of both compact and spongy bone tissues. Following comprehensive in vitro and in vivo biocompatibility studies\, nanocellulose with varied surface chemistries was employed to fine-tune nanostructured\, multi-material inks derived from a diverse library of biopolymers\, including gelatin\, gelatin methacryloyl\, alginate\, fibrin\, polyesters\, and polycarbonates. In formulations where human mesenchymal stromal/stem cells were incorporated into hydrogel precursors and printed to mimic bone extracellular matrix\, nanocellulose imparted exceptional shear-thinning properties\, effectively overcoming the rheological limitations associated with nanoceramic printing. To address the mechanical weakness of printed hydrogels and better emulate the load-bearing nature of compact bone\, a modified 3D printing strategy using thermoplastic polymers with bone-inspired designs was employed. These thermoplastic scaffolds were further coated with nanocellulose or magnesium-doped nanohydroxyapatite to enhance cellular integration and biological performance. \nFinally\, the lecture will discuss opportunities to integrate 3D printing technologies for tissue engineering and personalized medicine into UNAM’s research and entrepreneurial initiatives\, with the aim of advancing these innovations toward clinical application and achieving meaningful real-world impact. \n  \nAbout speaker\nDr. Ahmad Rashad Elsebahy is a dentist and tissue engineering researcher dedicated to bridging clinical needs with cutting-edge regenerative medicine. He is currently a Senior Researcher at the University of Bergen’s Tissue Engineering Group in Norway\, and also holds research affiliations with the Terasaki Institute for Biomedical Innovation (USA) and the University of Notre Dame’s Bioengineering Program (USA). Dr. Ahmad Rashad is a graduate of Alexandria University’s School of Dentistry in Egypt. He practiced dentistry for six years\, including a year-long residency in oral surgery\, before transitioning to tissue engineering research. His career has spanned three continents\, beginning with a Master’s in Biomaterials Science between Alexandria and Lehigh (USA) Universities\, where he engineered nanoporous bioactive glass scaffolds. In Japan at Nagasaki Dental School\, he developed regenerative dental nanomaterials\, followed by a PhD at the University of Bergen (Norway) focusing on 3D bioprinting stem cells in nanocellulose hydrogels. During his postdoc in Norway\, he established the group’s biofabrication platform\, secured over €4 million in grants\, co-founded Bergen’s first clinical startup for 3D-printed bone implants\, and patented several novel bone tissue engineering scaffolds. At the Terasaki Institute and Notre Dame\, his research expanded into personalized medicine\, shear-thinning nanomaterials\, biosensors\, microfluidics\, bioethics\, and stem cell–based bioprinted scaffolds for diabetic wound healing using cell-derived exosomes. With 40+ publications\, mentorship of 6 PhD and 3 Master’s students\, and co-founding a MedTech startup\, Dr. Ahmad Rashad exemplifies the fusion of clinical insight\, bioengineering innovation\, and translational vision to advance the future of regenerative therapies \n \n  \n 
URL:https://unam.bilkent.edu.tr/en/event/engineering-tissues-layer-by-layer-3d-bioprinting-with-bioinspired-nanomaterials/
CATEGORIES:UNAM Seminars
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DTSTART;TZID=Europe/Moscow:20250717T154000
DTEND;TZID=Europe/Moscow:20250717T170000
DTSTAMP:20260906T010718
CREATED:20250711T065312Z
LAST-MODIFIED:20250711T065312Z
UID:9918-1752766800-1752771600@unam.bilkent.edu.tr
SUMMARY:Engineering light to hop or walk through photonic nanostructures: Fundamental puzzles to sustainable industrial applications
DESCRIPTION:Willem L. Vos\nUniversity of Twente \n\nThe study of the propagation of light through complex composite materials – e.g.\, paint\, foam\, bio-logical tissue – is a topic that has become a field of its own [Nov2012\, Car2021]. This may seem surprising: if a material is so opaque that it scrambles images\, how can one see through? If a laser beam is scram¬bled\, how does optical interference survive? The answer is in essence that interferences survive even millions of scattering events\, observable as speckle or enhanced back scattering. Know-how of light scattering serves to address challenges in high-tech industry – from lighting\, CMOS metrology\, to atmospheric sensing – for sustainable technology\, see Fig. 1 [FFSO].\n \nFigure 1. Schematic illustrating how the joint engineering of broadband light waves by nanostructure and wavefront shaping optimizes light on a target\, for sustainable high-tech appli¬cations. \nThree complementary tools are crucial to control light interference in complex materials: nanostructure\, shape (freeform)\, wavefront shaping. (1) Much progress is made to realize nanostructures: periodic [Goo2023]\, cav¬ity superlattices [Adh2024]\, or chiral [Ota2019]. The chal-lenge to get calibrated densities is met by using in situ X-ray imaging. Since X-ray methods are non-destructive\, devices are available for further study or integration [Sch2024]. (2) External sample shape\, long neglected\, is remarkably crucial\, as known in industry\, and now also in wavefront shaping [Rat2023a]. (3) Wavefronts shaped with SLMs offer many control parameters to meet a desi¬red goal like a highly optimized focus (Fig. 1). This is used to send light deep into a forbidden gap [Upp2021]\, or do secure optical communication [Rat2023b]. A new topic is mutual scattering where extinction (shadow) is control¬led to make objects more transparent or darker\, or sense particle displacement in opaque materials [Rat2024\, Tru2022]. \nFinally\, even the transport of light intensity without interference – at the basis of most scattering optics – still holds puzzles\, notably when well-known models like diffusion break down [Akd2024]. \n  \n[Akd2024] O. Akdemir\, M. D. Truong\, A. Rates\, A. Lagendijk & WLV\, Phys. Rev. A 110 (2024) 033520\n[Car2021] R. Carminati & J. Schotland\, Principles of scattering and transport of light (Cambridge\, 2021)\n[FFSO] See www.freeformscatteringoptics.com; research program of 3 TUs and 6 hi-tech companies\n[Goo2023] M.J. Goodwin\, C.A.M. Harteveld\, M.J. de Boer\, et al.\, Nanotechnology 34 (2023) 225301\n[Koz2022] M. Kozoň\, A. Lagendijk\, et al.\, Phys. Rev. Lett. 129 (2022) 176401; Opt. Express (2023)\n[Nov2012] L. Novotny & B. Hecht\, Principles of Nano-optics (Cambridge\, 2012)\n[Ota2019] Y. Ota\, F. Liu\, R. Katsumi\, et al.\, Y. Arakawa & S. Iwamoto\, Optica 6 (2019) 786\n[Rat2023a] A. Rates\, A. Lagendijk\, A. J. L. Adam\, W. L. Ijzerman & WLV\, Opt. Express 31 (2023) 43351\n[Rat2023b] A. Rates\, J. Vrehen\, L. Mulder\, W. L. Ijzerman & WLV\, Opt. Express 31 (2023) 23897\n[Rat2024] A. Rates\, A. Lagendijk\, M. D. Truong & WLV\, Phys. Rev. A 110 (2024) 063518\n[Sch2024] A. S. Schulz\, M. Kozoň\, G. J. Vancso\, J. Huskens & WLV\, J. Phys. Chem. C 128 (2024) 9142\n[Tru2022] M.D. Truong\, A. Lagendijk & W.L. Vos\, Opt. Express 31\, 15058 (2023)\n[Upp2021] R. Uppu\, M. Adhikary\, C.A.M. Harteveld & W.L. Vos\, Phys. Rev. Lett. 126 (2021) 177402 \nAbout speaker\nWillem Vos obtained a Ph.D. in physics at the University of Amsterdam with highest honors (cum laude\, top 5%) for his thesis “Phase behavior of simple systems at high pressure”. He held a prestigious Fellowship from the Carnegie Institution for Science (USA) where he discovered a novel class of “van der Waals compounds” at very high pressures in the Geophysical Laboratory (Nature 1992).\nHe then became one of the first to study photonic crystals at optical frequencies\, niftily combining colloid physics and synchrotron X-ray methods. His team developed powerful “inverse opal” photonic crystals\, reported in an influential Science paper (~2400 Google citations). Since 2002 Vos is professor of Complex Photonic Systems (COPS) at the University of Twente. His team demonstrated the first ever control of spontaneous emission of light with photonic crystals (Nature 2004)\, and with a complete 3D photonic band gap (PRL 2011).\nHis COPS team pioneered optical wavefront shaping\, a revolution in optics to “unscatter” scattered light\, leading to novel applications in imaging\, microscopy\, and optical communication using opaque materials. Vos leads major multi-million-euro-consortia that closely collaborate with major high-tech industries and SMEs (with 30 BEUR annual turnover)\, to solve practical high-tech problems with advanced nanophotonics.\nVos was elected Fellow of the APS and of Optica (formerly: OSA)\, and awarded the Snellius medal and the Descartes-Huygens prize by the French Académie des Sciences. He has been guest professor at leading institutions (LPMMC\, CNRS\, Grenoble\, and Langevin Institute\, ESPCI\, PSL\, Paris). His papers are on average cited >40x. Willem Vos takes much pride in his students who have become faculty members at leading institutes\, or pursue careers in major industries as well as in non-profit organizations. \n  \n \n 
URL:https://unam.bilkent.edu.tr/en/event/engineering-light-to-hop-or-walk-through-photonic-nanostructures-fundamental-puzzles-to-sustainable-industrial-applications/
CATEGORIES:UNAM Seminars
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