{"id":3026,"date":"2016-12-12T11:32:08","date_gmt":"2016-12-12T08:32:08","guid":{"rendered":"http:\/\/localhost\/unam\/?p=3026"},"modified":"2021-02-08T11:33:25","modified_gmt":"2021-02-08T08:33:25","slug":"ultra-rapid-determination-of-erythrocyte-sedimentation-rate","status":"publish","type":"post","link":"https:\/\/unam.bilkent.edu.tr\/en\/2016\/12\/12\/ultra-rapid-determination-of-erythrocyte-sedimentation-rate\/","title":{"rendered":"Ultra rapid determination of erythrocyte sedimentation rate"},"content":{"rendered":"
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The erythrocyte sedimentation rate (ESR) is an important clinical test that screens several inflammatory conditions, infections, trauma, as well as non-inflammatory conditions such as stroke. The current standard test for ESR measurement is Westergren assay, which is a 1 h long test requiring a few ml of whole blood and trained technical personnel.<\/p>\n

Despite their simplicity, erythrocytes present several interesting behaviors. Erythrocyte aggregation (EA) is a physiochemical phenomenon where erythrocytes form reversible face-to-face linear structures. UNAM researchers, Ziya I\u015f\u0131ksa\u00e7an and Dr. \u00c7a\u011flar Elb\u00fcken, studied these fundamental properties of erythrocytes and explained the relationship between ESR and EA. Together with Prof. Ozcan Erel from Ankara Yildirim Beyazit University Faculty of Medicine, the team has developed a novel microfluidic system that measures ESR at the point-of-care in 2 min using 40 \u03bcl of whole blood. This work is presented as a cover article published on Lab on a Chip.<\/p>\n

The point-of-care system measures ESR by optically investigating the aggregation \/ disaggregation kinetics of erythrocytes in real-time. The validation tests performed at Atat\u00fcrk Hospital have confirmed that the results obtained with the developed system have a high correlation with the conventionally used gold standard Westergen method.<\/p>\n

Dr. Elb\u00fcken has pointed out: \u201cWe are thrilled to see that microfluidic tools can help us explain some very basic physiological behaviors of cells.\u201d Also, the Ph.D. student Ziya I\u015f\u0131ksa\u00e7an has added: \u201cWith the point-of-care platforms we are developing in our lab, we aim at decreasing the number of physician\/hospital visits by individuals and diminishing their medical expenses.\u201d<\/p>\n

The article has been featured as an Inside Front Cover in\u00a0Lab Chip<\/em>, 2016, 16, 4682 and can be accessed at the journal website:<\/p>\n

http:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2016\/lc\/c6lc01036a<\/a><\/p>\n<\/div>\n<\/div>\n

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Ziya I\u015f\u0131ksa\u00e7an<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u00d6zcan Erel<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u00c7a\u011flar Elb\u00fcken<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The erythrocyte sedimentation rate (ESR) is an important clinical test that screens several inflammatory conditions, infections, trauma, as well as non-inflammatory conditions such as stroke. 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