{"id":10597,"date":"2026-04-06T15:41:16","date_gmt":"2026-04-06T12:41:16","guid":{"rendered":"https:\/\/unam.bilkent.edu.tr\/en\/?post_type=tribe_events&#038;p=10597"},"modified":"2026-04-07T08:12:50","modified_gmt":"2026-04-07T05:12:50","slug":"building-a-minimal-nucleus-to-understand-structure-and-mechanics-of-assembly","status":"publish","type":"tribe_events","link":"https:\/\/unam.bilkent.edu.tr\/en\/event\/building-a-minimal-nucleus-to-understand-structure-and-mechanics-of-assembly\/","title":{"rendered":"Building a minimal nucleus to understand structure and  mechanics of assembly"},"content":{"rendered":"<h5>Alexander Von Appen<\/h5>\n<p>MPI of Molecular Cell Biology and Genetics<\/p>\n<hr \/>\n<p>The nucleus, the largest organelle in human cells, plays a crucial role in protecting, organizing, and regulating our genome. Despite its complexity, it undergoes remarkable dynamics during cell division: as the cell enters mitosis, nuclear organization dissolves, leading to the detachment of the nuclear membrane from chromatin. The nucleoplasm and cytoplasm merge into a single entity, while the spindle distributes chromosomes to form daughter cells. Following this \u201copen\u201d mitosis, the entire organelle reassembles within minutes, prompting the central question: what molecular mechanisms drive nuclear self-assembly?<\/p>\n<p>I will present our latest efforts to reconstitute nuclear self-assembly processes, which we study structurally using cryo-electron tomography and mechanically using optical tweezers. Specifically, I will show how ESCRT proteins assemble to close the nuclear membrane and how DNA is organized at the chromatin\u2013nuclear membrane interface.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-10600\" src=\"http:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Von-Appen-abstract.png\" alt=\"\" width=\"974\" height=\"962\" srcset=\"https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Von-Appen-abstract.png 974w, https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Von-Appen-abstract-300x296.png 300w, https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Von-Appen-abstract-768x759.png 768w\" sizes=\"auto, (max-width: 974px) 100vw, 974px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>About speaker<\/strong><\/h3>\n<p>PhD, EMBL Heidelberg, with Martin Beck, studying the structure of the human nuclear pore complex PostDoc, UCSF San Francisco, with Adam Frost, studying the role of phase separation in ESCRT-mediated nuclear membrane assembly Since 2021, Research Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-10602\" src=\"http:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Alexander-von-Appen-poster.jpg\" alt=\"\" width=\"1754\" height=\"2480\" srcset=\"https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Alexander-von-Appen-poster.jpg 1754w, https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Alexander-von-Appen-poster-212x300.jpg 212w, https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Alexander-von-Appen-poster-724x1024.jpg 724w, https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Alexander-von-Appen-poster-768x1086.jpg 768w, https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Alexander-von-Appen-poster-1086x1536.jpg 1086w, https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Alexander-von-Appen-poster-1448x2048.jpg 1448w, https:\/\/unam.bilkent.edu.tr\/en\/wp-content\/uploads\/2026\/04\/Alexander-von-Appen-poster-1200x1697.jpg 1200w\" sizes=\"auto, (max-width: 1754px) 100vw, 1754px\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alexander Von Appen MPI of Molecular Cell Biology and Genetics The nucleus, the largest organelle in human cells, plays a crucial role in protecting, organizing, and regulating our genome. Despite [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10598,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[59],"class_list":["post-10597","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-nanocolloquium-series","cat_nanocolloquium-series"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.13 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Building a minimal nucleus to understand structure and mechanics of assembly - UNAM Nanoteknoloji Ara\u015ft\u0131rma Merkezi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/unam.bilkent.edu.tr\/en\/event\/building-a-minimal-nucleus-to-understand-structure-and-mechanics-of-assembly\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Building a minimal nucleus to understand structure and mechanics of assembly - UNAM Nanoteknoloji Ara\u015ft\u0131rma Merkezi\" \/>\n<meta property=\"og:description\" content=\"Alexander Von Appen MPI of Molecular Cell Biology and Genetics The nucleus, the largest organelle in human cells, plays a crucial role in protecting, organizing, and regulating our genome. 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