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X-ORIGINAL-URL:https://unam.bilkent.edu.tr
X-WR-CALDESC:UNAM Nanoteknoloji Araştırma Merkezi için etkinlikler
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DTSTART:20240101T000000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Moscow:20240306T110000
DTEND;TZID=Europe/Moscow:20240306T123000
DTSTAMP:20260918T050657
CREATED:20240228T131835Z
LAST-MODIFIED:20240228T131859Z
UID:9089-1709722800-1709728200@unam.bilkent.edu.tr
SUMMARY:Multiscale Simulation Approaches to Understanding the Control of Trafficking in Cells
DESCRIPTION:Philip Biggin\nBiochemistry – University of Oxford \n\nMultiscale Simulation Approaches to Understanding\nthe Control of Trafficking in Cells \nTrafficking receptors control protein localisation through the recognition of specific signal sequences that specify unique cellular locations. Differences in luminal or organellular pH are important for the vectorial trafficking of cargo receptors. The KDEL receptor is responsible for maintaining the integrity of the ER by retrieving luminally localised folding chaperones in a pH-dependent mechanism. Structural studies have revealed the end states of KDEL receptor activation and the mechanism of selective cargo binding. However\, precisely how the KDEL receptor responds to changes in luminal pH remains unclear. To address this key question of cell biology\, we have used a combination of X-ray crystallography\, cell-based assays and multi-scale simulation methods. In this talk I will discuss how we have used a variety of computational techniques including QM\, GCMC\, MD and coarse-grained MD to explain how this cellular trafficking works at the molecular level. \n \nKonuşmacı hakkında\nPhilip Biggin is Professor of Computational Biochemistry in the Department of Biochemistry at the University of Oxford. He studied Computer-aided Chemistry at the University of Surrey for his undergraduate degree before completing a DPhil (PhD) in molecular biophysics at the University of Oxford. He then obtained a Wellcome Trust International Prize Fellowship that allowed him to undertake post-doctoral work at the Salk Institute\, California. He returned to Oxford in 2000 for further post-doctoral work\, before being awarded a prestigious RCUK Fellowship (with tenure track) in 2007. In 2012 this post reverted automatically to an Associate Professor (tenured). In 2016 he was made Full Professor at the University of Oxford. \nHis interests are focussed on the development and application of computational methods with particular respect to membrane proteins and membrane-drug interactions. He has over 150 peer-reviewed publications in this field\, and has previously acted as a consultant to BioMedCentral. He served as Chair of the Molecular Graphics and Modelling Society for over 10 years and is a Fellow of the Royal Society of Chemistry (FRSC) as well as a chartered chemist (CChem). He is a member of the British Biophysical Society and the US Biophysical Society. He was a founder member of CCPBioSim and HECBioSim committees that aim to promote the application of high-performance computing to biological problems. He also chaired allocation panels on PRACE – the European supercomputing facility. He has also served on the REF panel\, which is responsible for assessing the quality of UK science every seven years. His group has an excellent record in developing new approaches\, from assessing conformational states via normal mode analysis\, to a novel way to compare X-ray crystallographic data with molecular dynamics simulations and a way to align protein structures purely on the basis of their dynamics. \n \n  \n  \n\n  \n 
URL:https://unam.bilkent.edu.tr/etkinlikler/multiscale-simulation-approaches-to-understanding-the-control-of-trafficking-in-cells/
CATEGORIES:Nanokolokyumlar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Moscow:20240323T080000
DTEND;TZID=Europe/Moscow:20240324T170000
DTSTAMP:20260918T050657
CREATED:20240717T101838Z
LAST-MODIFIED:20240717T101838Z
UID:9566-1711180800-1711299600@unam.bilkent.edu.tr
SUMMARY:UNAM’da Dr. Urartu Şeker’in Öncülüğünde Düzenlenen Genetik Mühendislik Okulu ile 5. Kez Ortaokul Öğrencileri Bilimle Buluştu
DESCRIPTION:UNAM’da Dr. Urartu Şeker’in Öncülüğünde Düzenlenen Genetik Mühendislik Okulu ile 5. Kez Ortaokul Öğrencileri Bilimle Buluştu\nBilkent Üniversitesi Ulusal Nanoteknoloji Araştırma Merkezi’nin (UNAM) özgün bilgi üretmek ve nitelikli insan kaynağı yetiştirmek vizyonuyla Dr. Urartu Şeker öncülüğünde 5.si düzenlenen “Genetik Mühendisliği Okulu” ile ortaokul öğrencileri genetik mühendisliği ve sentetik biyoloji ile tanıştı. \n23-24 Mart 2024 tarihlerinde 12 öğrenci\, iki gün boyunca devam eden zengin program içeriği ile UNAM’ın altyapısında genetik mühendisliği ve biyokteknoloji konularında eğitim alırken aynı zamanda birlikte deney yapma ve çeşitli bilimsel yarışmalara dâhil olma imkânlarından faydalandılar. \n  \nProgram: \n23.03.2024 Cumartesi \n10.00-11.00: Tanışma ve Giriş Konuşmaları\n11.00-11.30: Ders I: Hücre: Canlıların yapıtaşları\n11.30-12.00: Ders II: Kalıtım\n12.00-13.00: Öğle Yemeği\n13.00-14.30: Deney 1: Bakterilere Gen Aktarımı (1. Kısım)\n14.30-15.00: Ders III: DNA ve Genetik Kod\n15.00-15.30: Deney 1: Bakterilere Gen Aktarımı (2. Kısım)\n15.30-16.00: Gün Değerlendirmesi\, Çıkış \n24.03.2024 Pazar \n10.00-10.30: İlk Günün Değerlendirmesi\n10.30-11.00: Ders IV: Santral Dogma ve Proteinler\n11.00-12.00: Deney 2: Hücresiz Ortamda Floresan Protein Üretimi\n12.00-13.00: Öğle Yemeği\n13.00-14.00: Deney 3: Gen Aktarılan Bakterilerin İncelenmesi\n14.00-14.30: Ders V: Biyoteknoloji\, Kavramlar ve Araçlar\n14.30-15.30: Deney 4: Üretilen Floresan Proteinlerinin İncelenmesi\n15.30-16.00: Gün Değerlendirmesi\, Çıkış
URL:https://unam.bilkent.edu.tr/etkinlikler/unamda-dr-urartu-sekerin-onculugunde-duzenlenen-genetik-muhendislik-okulu-ile-5-kez-ortaokul-ogrencileri-bilimle-bulustu/
CATEGORIES:UNAM Etkinlikler
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BEGIN:VEVENT
DTSTART;TZID=Europe/Moscow:20240326T080000
DTEND;TZID=Europe/Moscow:20240326T170000
DTSTAMP:20260918T050657
CREATED:20240717T120305Z
LAST-MODIFIED:20240717T120305Z
UID:9612-1711440000-1711472400@unam.bilkent.edu.tr
SUMMARY:Bilkent Üniversitesi UNAM Çevrimiçi Open
DESCRIPTION:Bilkent Üniversitesi UNAM Çevrimiçi Open\nUlusal Nanoteknoloji Araştırma Merkezi’ni (UNAM) keşfetmek\, UNAM’ın Malzeme Bilimi ve Nanoteknoloji (MSN) yükseköğrenim programı hakkında bilgi edinmek\, öğrenci hayatını ve çok daha fazlasını keşfetmek için 23 Mart 2024’te Bilkent Üniversitesi Çevrimiçi Open House etkinliğinde aday öğrencilerle bir araya geldik.
URL:https://unam.bilkent.edu.tr/etkinlikler/bilkent-universitesi-unam-cevrimici-open/
CATEGORIES:UNAM Etkinlikler
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